Advantages of Sodium Tert-Butoxide

 

Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5)

Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) is the chemical compound with the formula C4H9NaO. It is a strong base and a non-nucleophilic base. It is flammable and moisture sensitive. It is sometimes written in chemical literature as sodium t-butoxide. It is similar in reactivity to the more common potassium tert-butoxide.

Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) is used as a strong base and a non-nucleophilic base. In organic synthesis, it serves as an intermediate in various reactions like condensation, rearrangement and ring-opening. Further, it finds use in agrochemicals, pharmaceuticals, colorants, aroma chemicals, detergents and biodiesel. It acts as a catalyst in polymerization and isomerization reactions.The compound can be produced by treating tert-butyl alcohol with sodium hydride.

Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) Advantages

● High purity >99%

● Stable supply capability: 1000tons/Year

● Standard packaging and storage

● Warranty: if there are quality problems, we can negotiate a refund or exchange

 

Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) Application

● Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) is a white crystal widely used as a strong base in chemical, pharmaceutical, pesticide, and organic synthesis in condensation, rearrangement, and ring-opening reactions. Stable at room temperature and pressure. Avoid contact with potent reducing agents, moisture, air, and acid. Slightly harmful to water, avoid contact with groundwater, waterways, or sewage systems for undiluted or large quantities of Chemicalbook products; do not discharge the material into the surrounding environment without government permission. They are used as organic synthesis intermediates and pharmaceutical intermediates; used as solid bases in condensation, rearrangement, and ring-opening reactions in the organic synthesis of chemicals, pharmaceuticals, and pesticides.

● Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) can be used as a safe and effective alternative to sodium hydride for the coupling of hydroxyethyl adenine and diethyl p-tosylmethoxy methylphosphonate to form 9-[2-(diethylphosphonomethoxy)ethane]adenine (diethyl-PMEA), an important intermediate for the preparation of adefovir.

●Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) can also be used for Auxiliary coupling reactions of halogenated aromatics with benzene derivatives in the presence of 10-phenanthroline products.

● Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) can activate first-para-group transition metal precatalysts.

● A base for the amination of aryl chlorides in the presence of a novel cyclopalladated precatalyst.

●Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) is as a non-nucleophilic base. It has been widely used in the Buchwald–Hartwig amination, as in this typical example:

 

●Sodium Butoxide(Sodium Tert Butoxide CAS NO:865-48-5) is used to prepare tert-butoxide complexes. For example hexa(tert-butoxy)ditungsten(III) is thus converted by the salt metathesis reaction from a ditungsten heptachloride:

NaW2Cl7(THF)5 + 6 NaOBu-t → W2(OBu-t)6 + 7 NaCl + 5 THF

 

Safety Instructions:

● Hazardous Material Symbol: F, C, Xi

● Hazardous Category Code: 11-14-34-37-35-36/37/38-40-19

● Full description: 26-36/37/39-43-45-7/8-8-8-16-Chemicalbook36

● Dangerous Goods Transport Number: UN32064.2/PG2

● WGK Germany: 3

● F: 1-3-10

● TSCA: Yes

● HazardClass: 8

● PackingGroup: II

Hazard Category

●Serious eye damage/eye irritation Category 1

●Flammable solid Category 1

●Self-heating substance Category 1

●Skin corrosion/irritation Category 1 B

Hazard Statement

●H318-Causes serious eye damage.

●H314-Causes severe skin burns and eye damage.

●H251-Self-heating: may catch fire.

●H228-Flammable solid.

●EUH014-Reacts violently with water.

Precautionary Statement

●P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

●P280-Wear protective gloves/protective clothing/eye protection/face protection.

●P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.

●P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

●P310-Immediately call a POISON CENTER/doctor/.

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